Endocrine Abstracts

Background: The incidence of type 1 diabetes mellitus is increasing worldwide with recent European data suggesting annual increases ranging from 0.6 to 9.3%, the overall rate being 3.9%. It was thought that the Republic of Ireland (ROI) had one of the lowest disease incidences in Europe. The first Irish study of T1DM incidence which provided a measure of case ascertainment, confirmed a high incidence rate (IR) at 16.6 per 100 000 placing this population, in the upper quartile ...

Turner Syndrome is a chromosomal disorder, which affects approximately 1 in 2500 live female births. It is associated with significant morbidity throughout childhood, adolescence and into adulthood. Quality of life is reduced in a significant number of females with Turner Syndrome due to lack of focused health care particularly during the transition from paediatric to adult services. The purpose of this study was to assess the health status and well being of a cohort of young ...

Background: Individuals born Small for Gestational age (SGA) are at high risk of development of type 2 diabetes. Growth hormone (GH) therapy can also adversely affect glucose metabolism.Aim: To explore the factors associated with changes in insulin sensitivity (IS) and insulin secretion during one year of GH treatment in children born SGA.Methods: In the NESGAS clinical trial, we studied 82 (55♂) pre-pubertal children (age 3....